ABSTRACT
Objective To study the application value of pidotimod oral solution in children with recurrent respiratory tract infections (RRTIs).Methods Ninety-two children with RRTIs were divided into observation group and control group by random digits table method with 46 cases each.The children in control group were given conventional treatment.The children in observation group were added pidotimod oral solution on the basis of conventional treatment.The serum immunoglobulin (lg) G,IgM,IgA,and peripheral blood T lymphocyte subgroup (CD3+,CD4+,CD8+) before and after treatment,improvement of clinical symptoms and signs,the recurrence time of respiratory tract infections during 1 year after treatment,and untoward reaction were compared between 2 groups.Results The IgG,IgM and IgA levels after treatment in observation group were significantly higher than those in control group:(9.98 ± 2.26) g/L vs.(8.49 ± 2.23) g/L,(1.27 ± 0.28) g/L vs.(1.10 ± 0.21) g/L,(0.95 ± 0.27) g/L vs.(0.72 ± 0.23) g/L,and there were statistical differences (P ＜ 0.05).The CD3+ and CD4+ levels after treatment in observation group were significantly higher than those in control group:0.706 ± 0.087 vs.0.630 ± 0.069,0.456 ± 0.047 vs.0.348 ± 0.034,and CD8+ level was significantly lower than that in control group:0.177 ± 0.046 vs.0.212 ± 0.041,and there were statistical differences (P ＜ 0.05).The time to defervesce,disappearing time of coughing,disappearing time of tonsil swelling and disappearing time of lung rale in observation group were significantly shorter than those in controlgroup:(2.82±0.71)d vs.(3.86± 1.11) d,(4.26± 1.54)d vs.(5.69± 1.82) d,(3.12± 1.02) d vs.(4.67 ± 1.40) d,(3.35 ± 1.58) d vs.(4.75 ± 1.58) d,and there were statistical differences (P ＜ 0.05).The recurrence time of respiratory tract infections during 1 year after treatment in observation group was significantly lower than that in control group:(5.08 ± 1.61) times vs.(7.25 ± 1.68) times,and there was statistical difference (P＜ 0.05).The untoward reaction was not found in the 2 groups.Conclusion Pidotimod oral solution has the prevention and treatment effect in children with RRTIs.
ABSTRACT
Objective:To observe the effects and adverse reactions of tulobuterol patches in the adjuvant treatment of capillary bronchitis to elucidate the treatment effect of tulobuterol patches in the patients with capillary bronchitis. Methods:A total of 160 chil-dren with capillary bronchitis were randomly divided into the observation group and the control group. Both groups were given conven-tional therapy:oxygen treatment, aerosol inhalation of budesonide and anti-infection, etc. The control group was given nebulized al-buterol aerosols additionally, while the observation group was received tulobuterol patches additionally. The disappearance time of clini-cal symptoms and signs, the average length of stay in hospital and the incidence of adverse reactions between the two groups were com-pared. Results:In the observation group, the symptom of cough disappeared in (5. 08 ± 2. 35) d, wheezing disappeared in (3. 26 ± 1. 87)d, and the hospitalization time was (6. 15 ± 2. 27) d. Compared with those in the control group, the above indices were all shor-ter with statistically significant difference (P<0. 05). The incidence of adverse reactions was 3. 75% in the observation group while 38. 75% in the control group, the difference was statistically significant(P<0. 05) . Conclusion:Tulobuterol patches in the adjuvant treatment of capillary bronchitis can improve the clinical curative effect with promising safety and practicability.